Hematopoietic Stem Cell Transplantation

Jelena L. Holovati, PhD, BSc(MLS), MT(ASCP) | May 27, 2017 | 51min

Hematopoietic stem cell (HSC) transplantation following myeloablative therapy is a rapidly evolving medical intervention offering a potential cure for many hematologic cancers and disorders. HSCs are derived from bone marrow, peripheral blood, or cord blood.  For bone marrow HSC harvest, ~1000 mL of marrow is aspirated from the donor’s posterior iliac crests.  For peripheral blood HSC harvest, the donor is treated with recombinant growth factor(s) to stimulate proliferation of HSCs, following by an apheresis collection.  Umbilical cord blood can also serve as a rich source of HPCs.  This presentation will discuss the role of laboratory in processing, evaluating, and storing HPCs for transplant applications.


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